Grenac-SP

Description

Aceclofenac Is A Phenylacetic Acid Derivative That Inhibits Synthesis Of The Inflammatory Cytokines Interleukin-1b And Tumour Necrosis Factor, And Inhibits Prostaglandin E2 Production. It Increases Glycosaminoglycans (GAG) Synthesis, The Principal Macromolecule Of The Extracellular Matrix, Which Aids In Repair And Regeneration Of Articular Cartilage. Thus, Aceclofenac Has +Ve Effects On Cartilage Anabolism Combined With Modulating Effect Of Matrix Catabolism. Paracetamol Has Analgesic And Antipyretic Action With Weak Anti-Inflammatory Activity. It Produces Analgesia By Increasing Pain Threshold And Antipyresis By Acting On The Hypothalamic Heat-Regulating Centre. Absorption: Aceclofenac: Rapidly Absorbed; Almost 100% Bioavailability; Peak Plasma Levels Reached About 1.25-3 Hr After Oral Admin. Distribution: Aceclofenac: >99.7% Bound To Plasma Proteins; Distributes Into Synovial Fluid. Paracetamol: Distributes Throughout Most Fluids Of The Body. Metabolism: Aceclofenac: Probably Metabolised By CYP2C9; Average Plasma Elimination Half-Life: 4-4.3 Hr. Paracetamol: Mainly Metabolised Hepatically; Plasma Elimination Half-Life: 1-4 Hr. Excretion: Aceclofenac: About Two-Thirds Of The Administered Dose Is Removed In The Urine, Mainly As Conjugated Hydroxymetabolites. Paracetamol: Most Metabolites Are Removed In The Urine Within 24 Hr.